DSIP
Also known as: Delta Sleep-Inducing Peptide
A naturally occurring nine-amino-acid neuropeptide named for its association with deep (delta-wave) sleep, studied for sleep, stress and pain modulation.
DSIP at a glance
| Name | DSIP |
|---|---|
| Also known as | Delta Sleep-Inducing Peptide |
| Category | Sleep & stress |
| Type | Peptide |
| Sequence | Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu |
| Typical dose | ~100–300 mcg per dose |
| Frequency | Typically before sleep |
| Route | Subcutaneous injection (research) |
| Half-life | Very short — on the order of minutes in circulation. |
Overview
DSIP was first identified for its apparent ability to promote delta-wave (deep) sleep. It is a small, naturally occurring peptide found in the brain, and beyond sleep it has been linked in research to stress resilience, pain modulation and effects on several hormones. Its exact mechanism is still not well understood, and study results have been inconsistent — which keeps it firmly in the experimental category.
How it’s thought to work
- Appears to modulate sleep architecture, favoring slow-wave (delta) sleep.
- Interacts with stress systems and may buffer the response to stressors.
- Reported influences on hormones (e.g. LH, GH) and pain thresholds, though findings vary.
Researched uses
- Sleep quality and normalization of disturbed sleep
- Stress and anxiety modulation
- Pain and withdrawal-related research
Commonly cited protocol
| Typical dose | ~100–300 mcg per dose |
|---|---|
| Frequency | Typically before sleep |
| Route | Subcutaneous injection (research) |
| Notes | Response is notably variable between individuals in the literature. |
Reconstitution
Often a 5 mg vial. Reconstituting 5 mg with 2 mL of bacteriostatic water gives 2.5 mg/mL, so 250 mcg = 10 units on a U-100 syringe.
DSIP dosage calculator
The calculator below is pre-filled with DSIP’s commonly cited vial size and dose. Adjust the vial amount, bacteriostatic water, or dose to match your own vial — it will show the exact insulin-syringe units to draw, the concentration, and how many doses the vial holds.
Add 2 mL of bacteriostatic water to your 5 mg vial. That gives you about 20 doses of 250 mcg. For each dose, draw 10 units into a 100-unit insulin syringe.
See the full DSIP dosing chart (units for every dose & water amount), or open the full peptide calculator →
Cautions
- Not FDA approved; evidence is mixed and mostly older/small studies.
- Effects and reliability differ widely between users in reports.
- Purity of research-grade peptide varies by source.
DSIP FAQ
What is DSIP?
A naturally occurring nine-amino-acid neuropeptide named for its association with deep (delta-wave) sleep, studied for sleep, stress and pain modulation.
How does DSIP work?
Appears to modulate sleep architecture, favoring slow-wave (delta) sleep. Interacts with stress systems and may buffer the response to stressors. Reported influences on hormones (e.g. LH, GH) and pain thresholds, though findings vary.
What is DSIP used for?
Sleep quality and normalization of disturbed sleep; Stress and anxiety modulation; Pain and withdrawal-related research.
What is a typical DSIP dose?
~100–300 mcg per dose, Typically before sleep, Subcutaneous injection (research). This is a commonly cited figure for context only, not medical advice.
How do you reconstitute DSIP?
Often a 5 mg vial. Reconstituting 5 mg with 2 mL of bacteriostatic water gives 2.5 mg/mL, so 250 mcg = 10 units on a U-100 syringe.
What is the half-life of DSIP?
Very short — on the order of minutes in circulation.