HGH Fragment 176-191
Also known as: HGH Frag 176-191 · AOD-9604 (related analogue) · Lipolytic fragment
A short fragment corresponding to the C-terminal region of human growth hormone, studied mainly for its reported fat-mobilizing (lipolytic) activity without the broader growth effects of full GH.
HGH Fragment 176-191 at a glance
| Name | HGH Fragment 176-191 |
|---|---|
| Also known as | HGH Frag 176-191, AOD-9604 (related analogue), Lipolytic fragment |
| Category | Fat loss & metabolism |
| Type | Peptide |
| Sequence | 16-amino-acid C-terminal fragment of human growth hormone (residues 176-191) |
| Typical dose | ~250-500 mcg per day |
| Frequency | Once or split across the day, often on an empty stomach |
| Route | Subcutaneous injection (research) |
| Half-life | Short - estimated at roughly 30 minutes; not firmly established in humans. |
Overview
HGH Fragment 176-191 is a synthetic peptide representing the tail end of the growth-hormone molecule. Research interest centers on the observation that this region appears to carry much of GH's fat-metabolizing activity while largely lacking its effects on IGF-1 and blood glucose. Most supporting data come from animal and laboratory studies; robust human evidence is limited. It is an investigational compound, not an approved drug.
How it’s thought to work
- Appears to stimulate lipolysis (breakdown of stored fat) in adipose tissue.
- Thought to reduce lipogenesis, limiting new fat accumulation.
- Reported to act largely independently of the IGF-1 pathway in research models.
- Mimics the fat-regulating portion of full-length growth hormone.
Researched uses
- Fat reduction and body-composition research in animal models
- Investigating GH-independent lipolytic pathways
- Comparative studies with the related analogue AOD-9604
Commonly cited protocol
| Typical dose | ~250-500 mcg per day |
|---|---|
| Frequency | Once or split across the day, often on an empty stomach |
| Route | Subcutaneous injection (research) |
| Notes | Fasted timing is frequently mentioned in research discussions of lipolytic peptides. |
Reconstitution
Commonly supplied as a 5 mg lyophilized vial. Reconstituting 5 mg with 2 mL of bacteriostatic water gives 2.5 mg/mL, so a 250 mcg dose is about 10 units on a U-100 syringe.
HGH Fragment 176-191 dosage calculator
The calculator below is pre-filled with HGH Fragment 176-191’s commonly cited vial size and dose. Adjust the vial amount, bacteriostatic water, or dose to match your own vial — it will show the exact insulin-syringe units to draw, the concentration, and how many doses the vial holds.
Add 2 mL of bacteriostatic water to your 5 mg vial. That gives you about 20 doses of 250 mcg. For each dose, draw 10 units into a 100-unit insulin syringe.
See the full HGH Fragment 176-191 dosing chart (units for every dose & water amount), or open the full peptide calculator →
Cautions
- A research chemical not approved by the FDA for human use; prohibited in competitive sport.
- Human efficacy data for fat loss remain limited and mixed.
- Long-term safety has not been established.
- Research-grade purity varies widely by source.
HGH Fragment 176-191 FAQ
What is HGH Fragment 176-191?
A short fragment corresponding to the C-terminal region of human growth hormone, studied mainly for its reported fat-mobilizing (lipolytic) activity without the broader growth effects of full GH.
How does HGH Fragment 176-191 work?
Appears to stimulate lipolysis (breakdown of stored fat) in adipose tissue. Thought to reduce lipogenesis, limiting new fat accumulation. Reported to act largely independently of the IGF-1 pathway in research models. Mimics the fat-regulating portion of full-length growth hormone.
What is HGH Fragment 176-191 used for?
Fat reduction and body-composition research in animal models; Investigating GH-independent lipolytic pathways; Comparative studies with the related analogue AOD-9604.
What is a typical HGH Fragment 176-191 dose?
~250-500 mcg per day, Once or split across the day, often on an empty stomach, Subcutaneous injection (research). This is a commonly cited figure for context only, not medical advice.
How do you reconstitute HGH Fragment 176-191?
Commonly supplied as a 5 mg lyophilized vial. Reconstituting 5 mg with 2 mL of bacteriostatic water gives 2.5 mg/mL, so a 250 mcg dose is about 10 units on a U-100 syringe.
What is the half-life of HGH Fragment 176-191?
Short - estimated at roughly 30 minutes; not firmly established in humans.