Humanin
Also known as: HN · Mitochondrial-derived peptide
A mitochondrial-derived peptide studied for cytoprotection, metabolism, and healthy aging.
Humanin at a glance
| Name | Humanin |
|---|---|
| Also known as | HN, Mitochondrial-derived peptide |
| Category | Longevity & mitochondrial |
| Type | Peptide |
| Sequence | 24-amino-acid mitochondrial-derived peptide |
| Typical dose | Research-scale (varies) |
| Frequency | Varies |
| Route | Subcutaneous injection |
| Half-life | Short. |
Overview
Humanin is a small peptide encoded in mitochondrial DNA (a cousin of MOTS-c) with broad cytoprotective effects. Research links it to protection of neurons, improved insulin sensitivity, and reduced cell death under stress, making it a longevity candidate.
How it’s thought to work
- Protects cells from apoptosis (programmed death) under stress.
- Improves insulin sensitivity and modulates metabolic and inflammatory pathways.
Researched uses
- Neuroprotection and healthy-aging research
- Metabolic and cardiovascular studies
Commonly cited protocol
| Typical dose | Research-scale (varies) |
|---|---|
| Frequency | Varies |
| Route | Subcutaneous injection |
| Notes | No established human protocol. |
Reconstitution
Often a 5 mg vial. 5 mg with 2 mL water = 2.5 mg/mL, so 250 mcg = 10 units on a U-100 syringe.
Humanin dosage calculator
The calculator below is pre-filled with Humanin’s commonly cited vial size and dose. Adjust the vial amount, bacteriostatic water, or dose to match your own vial — it will show the exact insulin-syringe units to draw, the concentration, and how many doses the vial holds.
Add 2 mL of bacteriostatic water to your 5 mg vial. That gives you about 20 doses of 250 mcg. For each dose, draw 10 units into a 100-unit insulin syringe.
See the full Humanin dosing chart (units for every dose & water amount), or open the full peptide calculator →
Cautions
- Not approved for human use.
- Human data are early.
- Research chemical status.
Humanin FAQ
What is Humanin?
A mitochondrial-derived peptide studied for cytoprotection, metabolism, and healthy aging.
How does Humanin work?
Protects cells from apoptosis (programmed death) under stress. Improves insulin sensitivity and modulates metabolic and inflammatory pathways.
What is Humanin used for?
Neuroprotection and healthy-aging research; Metabolic and cardiovascular studies.
What is a typical Humanin dose?
Research-scale (varies), Varies, Subcutaneous injection. This is a commonly cited figure for context only, not medical advice.
How do you reconstitute Humanin?
Often a 5 mg vial. 5 mg with 2 mL water = 2.5 mg/mL, so 250 mcg = 10 units on a U-100 syringe.
What is the half-life of Humanin?
Short.