Kisspeptin-10
Also known as: KP-10 · Metastin fragment
A signaling peptide that sits at the top of the reproductive hormone axis, studied for fertility and libido.
Kisspeptin-10 at a glance
| Name | Kisspeptin-10 |
|---|---|
| Also known as | KP-10, Metastin fragment |
| Category | Hormonal & reproductive |
| Type | Peptide |
| Sequence | 10-amino-acid active fragment of kisspeptin |
| Typical dose | ~1 mg (varies widely) |
| Frequency | Varies |
| Route | Subcutaneous injection |
| Half-life | Short (minutes). |
Overview
Kisspeptin is a master regulator of reproduction — it triggers the release of GnRH, which cascades down to LH, FSH, and the sex hormones. Kisspeptin-10 is the short active fragment, studied for fertility, hypogonadism, and sexual response.
How it’s thought to work
- Stimulates GnRH neurons, driving downstream LH/FSH and sex-hormone release.
- Sits upstream of the entire hypothalamic-pituitary-gonadal axis.
Researched uses
- Fertility and reproductive-hormone research
- Libido and hypogonadism studies
Commonly cited protocol
| Typical dose | ~1 mg (varies widely) |
|---|---|
| Frequency | Varies |
| Route | Subcutaneous injection |
| Notes | Clinical research uses precise, weight-based dosing. |
Reconstitution
Often a 5 mg vial. 5 mg with 2 mL water = 2.5 mg/mL, so 1 mg = 40 units on a U-100 syringe.
Kisspeptin-10 dosage calculator
The calculator below is pre-filled with Kisspeptin-10’s commonly cited vial size and dose. Adjust the vial amount, bacteriostatic water, or dose to match your own vial — it will show the exact insulin-syringe units to draw, the concentration, and how many doses the vial holds.
Add 2 mL of bacteriostatic water to your 5 mg vial. That gives you about 5 doses of 1 mg. For each dose, draw 40 units into a 100-unit insulin syringe.
See the full Kisspeptin-10 dosing chart (units for every dose & water amount), or open the full peptide calculator →
Cautions
- Not approved for general use.
- Affects the whole reproductive-hormone axis — effects can be complex.
- Consult a clinician, especially with hormone-sensitive conditions.
Kisspeptin-10 FAQ
What is Kisspeptin-10?
A signaling peptide that sits at the top of the reproductive hormone axis, studied for fertility and libido.
How does Kisspeptin-10 work?
Stimulates GnRH neurons, driving downstream LH/FSH and sex-hormone release. Sits upstream of the entire hypothalamic-pituitary-gonadal axis.
What is Kisspeptin-10 used for?
Fertility and reproductive-hormone research; Libido and hypogonadism studies.
What is a typical Kisspeptin-10 dose?
~1 mg (varies widely), Varies, Subcutaneous injection. This is a commonly cited figure for context only, not medical advice.
How do you reconstitute Kisspeptin-10?
Often a 5 mg vial. 5 mg with 2 mL water = 2.5 mg/mL, so 1 mg = 40 units on a U-100 syringe.
What is the half-life of Kisspeptin-10?
Short (minutes).