LL-37
Also known as: Cathelicidin · CAP-18 fragment
A natural antimicrobial peptide studied for infection defense, wound healing, and immune modulation.
LL-37 at a glance
| Name | LL-37 |
|---|---|
| Also known as | Cathelicidin, CAP-18 fragment |
| Category | Immune & antimicrobial |
| Type | Peptide |
| Sequence | 37-amino-acid cathelicidin-derived peptide |
| Typical dose | ~100 mcg (varies) |
| Frequency | Varies |
| Route | Subcutaneous injection |
| Half-life | Short. |
Overview
LL-37 is part of the body’s innate immune defense — a naturally occurring peptide that can disrupt bacteria, fungi, and viruses directly while also shaping the immune and healing response. Research spans chronic infections, biofilms, and wound repair.
How it’s thought to work
- Directly disrupts microbial membranes (broad antimicrobial action).
- Modulates immune signaling and supports wound healing and angiogenesis.
Researched uses
- Antimicrobial and biofilm research
- Wound healing and immune modulation
Commonly cited protocol
| Typical dose | ~100 mcg (varies) |
|---|---|
| Frequency | Varies |
| Route | Subcutaneous injection |
| Notes | Research dosing; can cause local reactions. |
Reconstitution
Often a 5 mg vial. 5 mg with 2 mL water = 2.5 mg/mL, so 100 mcg = 4 units on a U-100 syringe.
LL-37 dosage calculator
The calculator below is pre-filled with LL-37’s commonly cited vial size and dose. Adjust the vial amount, bacteriostatic water, or dose to match your own vial — it will show the exact insulin-syringe units to draw, the concentration, and how many doses the vial holds.
Add 5 mL of bacteriostatic water to your 5 mg vial. That gives you about 50 doses of 100 mcg. For each dose, draw 10 units into a 100-unit insulin syringe.
See the full LL-37 dosing chart (units for every dose & water amount), or open the full peptide calculator →
Cautions
- Not approved for human use.
- Can cause injection-site irritation/inflammation.
- At high levels it may have pro-inflammatory effects.
LL-37 FAQ
What is LL-37?
A natural antimicrobial peptide studied for infection defense, wound healing, and immune modulation.
How does LL-37 work?
Directly disrupts microbial membranes (broad antimicrobial action). Modulates immune signaling and supports wound healing and angiogenesis.
What is LL-37 used for?
Antimicrobial and biofilm research; Wound healing and immune modulation.
What is a typical LL-37 dose?
~100 mcg (varies), Varies, Subcutaneous injection. This is a commonly cited figure for context only, not medical advice.
How do you reconstitute LL-37?
Often a 5 mg vial. 5 mg with 2 mL water = 2.5 mg/mL, so 100 mcg = 4 units on a U-100 syringe.
What is the half-life of LL-37?
Short.