NAD+
Also known as: Nicotinamide adenine dinucleotide
A coenzyme central to cellular energy and repair, given by injection or IV for energy and longevity research.
NAD+ at a glance
| Name | NAD+ |
|---|---|
| Also known as | Nicotinamide adenine dinucleotide |
| Category | Longevity & cellular energy |
| Type | Amino / injectable |
| Sequence | A dinucleotide coenzyme (not a peptide) |
| Typical dose | Highly variable (tens to hundreds of mg) |
| Frequency | Varies |
| Route | Slow subcutaneous injection or IV infusion |
| Half-life | Short; often dosed as infusions. |
Overview
NAD+ (nicotinamide adenine dinucleotide) is a coenzyme found in every cell, essential for turning food into energy and for DNA-repair and sirtuin pathways tied to aging. Levels decline with age, which has driven interest in restoring it through injections and IV drips in wellness and longevity settings.
How it’s thought to work
- Serves as an essential coenzyme for mitochondrial energy (ATP) production.
- Fuels sirtuins and PARPs involved in DNA repair and cellular aging.
- Supports redox balance across metabolism.
Researched uses
- Energy and fatigue
- Longevity and cellular-repair research
- Recovery and cognitive support
Commonly cited protocol
| Typical dose | Highly variable (tens to hundreds of mg) |
|---|---|
| Frequency | Varies |
| Route | Slow subcutaneous injection or IV infusion |
| Notes | Injected too quickly it can cause flushing/discomfort — given slowly. |
Reconstitution
Usually supplied as a solution or large-mg vial for slow injection/IV, so simple insulin-unit dosing often does not apply.
Cautions
- Not an approved therapy for anti-aging.
- Rapid administration causes flushing, nausea, chest tightness.
- Evidence for many claimed benefits is limited.
NAD+ FAQ
What is NAD+?
A coenzyme central to cellular energy and repair, given by injection or IV for energy and longevity research.
How does NAD+ work?
Serves as an essential coenzyme for mitochondrial energy (ATP) production. Fuels sirtuins and PARPs involved in DNA repair and cellular aging. Supports redox balance across metabolism.
What is NAD+ used for?
Energy and fatigue; Longevity and cellular-repair research; Recovery and cognitive support.
What is a typical NAD+ dose?
Highly variable (tens to hundreds of mg), Varies, Slow subcutaneous injection or IV infusion. This is a commonly cited figure for context only, not medical advice.
How do you reconstitute NAD+?
Usually supplied as a solution or large-mg vial for slow injection/IV, so simple insulin-unit dosing often does not apply.
What is the half-life of NAD+?
Short; often dosed as infusions.