Alpha-GPC
Also known as: L-Alpha-glycerylphosphorylcholine · Choline alfoscerate · Alpha-glycerophosphocholine
A choline-containing compound, commonly cited in the research literature for context around acetylcholine support and cognition.
Alpha-GPC at a glance
| Name | Alpha-GPC |
|---|---|
| Also known as | L-Alpha-glycerylphosphorylcholine, Choline alfoscerate, Alpha-glycerophosphocholine |
| Category | Cognitive & neuroprotective |
| Type | Amino / injectable |
| Sequence | Non-peptide choline compound (L-alpha-glycerylphosphorylcholine) |
| Typical dose | ~300-600 mg per day (commonly cited) |
| Frequency | Once or twice daily |
| Route | Oral (supplement) |
| Half-life | Choline from Alpha-GPC is absorbed and metabolized over several hours. |
Overview
Alpha-GPC is a naturally occurring choline compound that serves as a source of choline for the body. It is sold as a dietary supplement in the United States and as a prescription cognition drug in some other countries. Research has examined it for cognitive support and, separately, for acute physical performance. Presented for educational context only.
How it’s thought to work
- Reported to raise choline availability for acetylcholine synthesis.
- Appears to support cell membrane phospholipid metabolism.
- Studied for effects on growth hormone release after acute dosing.
Researched uses
- Cognitive support in aging and dementia research
- Acute physical and power performance studies
- Recovery of cognition after stroke in regional trials
Commonly cited protocol
| Typical dose | ~300-600 mg per day (commonly cited) |
|---|---|
| Frequency | Once or twice daily |
| Route | Oral (supplement) |
| Notes | Taken orally as capsules or powder; some studies used higher acute doses before exercise. |
Reconstitution
Taken orally rather than injected, so insulin-syringe unit math does not apply.
Cautions
- Sold as a dietary supplement in the US; not an FDA-approved drug here.
- Some research links high long-term choline intake to cardiovascular markers, warranting caution.
- Quality and dose accuracy vary by brand.
- Not intended to diagnose or treat any condition.
Alpha-GPC FAQ
What is Alpha-GPC?
A choline-containing compound, commonly cited in the research literature for context around acetylcholine support and cognition.
How does Alpha-GPC work?
Reported to raise choline availability for acetylcholine synthesis. Appears to support cell membrane phospholipid metabolism. Studied for effects on growth hormone release after acute dosing.
What is Alpha-GPC used for?
Cognitive support in aging and dementia research; Acute physical and power performance studies; Recovery of cognition after stroke in regional trials.
What is a typical Alpha-GPC dose?
~300-600 mg per day (commonly cited), Once or twice daily, Oral (supplement). This is a commonly cited figure for context only, not medical advice.
How do you reconstitute Alpha-GPC?
Taken orally rather than injected, so insulin-syringe unit math does not apply.
What is the half-life of Alpha-GPC?
Choline from Alpha-GPC is absorbed and metabolized over several hours.