Selank
Also known as: Tuftsin analog · TP-7
A Russian-developed heptapeptide based on the immune peptide tuftsin, studied as a non-sedating anti-anxiety agent with cognitive and immune effects.
Selank at a glance
| Name | Selank |
|---|---|
| Also known as | Tuftsin analog, TP-7 |
| Category | Cognitive & neuroprotective |
| Type | Peptide |
| Sequence | Thr-Lys-Pro-Arg-Pro-Gly-Pro |
| Typical dose | ~250–500 mcg per day (0.15% solutions) |
| Frequency | Split through the day |
| Route | Intranasal (drops/spray) most commonly |
| Half-life | Short, but stabilized to last longer than native tuftsin. |
Overview
Selank is a stabilized synthetic analog of tuftsin, a naturally occurring immune-modulating peptide. Developed in Russia as an anxiolytic, it is designed to calm anxiety without the sedation, dependence or withdrawal associated with benzodiazepines. Research describes a mix of anti-anxiety, mild cognitive and immune-modulating effects. Like its cousin Semax, it is usually taken intranasally and is unapproved outside its region of origin.
How it’s thought to work
- Modulates GABA and serotonin systems tied to anxiety regulation.
- Influences BDNF and the balance of pro-/anti-inflammatory cytokines (tuftsin-like immune activity).
- May slow breakdown of enkephalins, extending calming signals.
Researched uses
- Generalized anxiety and stress without sedation
- Cognitive support and stress resilience
- Immune modulation in some studies
Commonly cited protocol
| Typical dose | ~250–500 mcg per day (0.15% solutions) |
|---|---|
| Frequency | Split through the day |
| Route | Intranasal (drops/spray) most commonly |
| Notes | Sometimes studied alongside Semax for combined mood/focus effects. |
Reconstitution
Typically prepared as a nasal solution, so syringe-unit dosing generally does not apply.
Cautions
- Not FDA approved; limited large-scale human trials in the West.
- Possible nasal irritation.
- Interactions with other serotonergic/anxiolytic agents are under-studied.
Selank FAQ
What is Selank?
A Russian-developed heptapeptide based on the immune peptide tuftsin, studied as a non-sedating anti-anxiety agent with cognitive and immune effects.
How does Selank work?
Modulates GABA and serotonin systems tied to anxiety regulation. Influences BDNF and the balance of pro-/anti-inflammatory cytokines (tuftsin-like immune activity). May slow breakdown of enkephalins, extending calming signals.
What is Selank used for?
Generalized anxiety and stress without sedation; Cognitive support and stress resilience; Immune modulation in some studies.
What is a typical Selank dose?
~250–500 mcg per day (0.15% solutions), Split through the day, Intranasal (drops/spray) most commonly. This is a commonly cited figure for context only, not medical advice.
How do you reconstitute Selank?
Typically prepared as a nasal solution, so syringe-unit dosing generally does not apply.
What is the half-life of Selank?
Short, but stabilized to last longer than native tuftsin.