Larazotide
Also known as: Larazotide acetate · AT-1001
An orally administered, locally acting gut-barrier peptide commonly cited in the research literature for context on intestinal permeability.
Larazotide at a glance
| Name | Larazotide |
|---|---|
| Also known as | Larazotide acetate, AT-1001 |
| Category | Gut & anti-inflammatory |
| Type | Peptide |
| Sequence | Gly-Gly-Val-Leu-Val-Gln-Pro-Gly |
| Typical dose | Commonly cited around 0.5 mg (500 mcg) before meals in trials |
| Frequency | Typically three times daily with meals |
| Route | Oral |
| Half-life | Not applicable in the usual systemic sense - it acts locally and is minimally absorbed. |
Overview
Larazotide is a synthetic octapeptide studied as a tight-junction regulator that acts within the gut lumen and is not meaningfully absorbed systemically. Much of its attention comes from celiac-disease research aimed at reducing intestinal permeability.
How it’s thought to work
- Appears to promote assembly of intestinal tight junctions.
- May reduce paracellular permeability of the gut lining.
- Acts locally in the intestinal lumen with minimal systemic absorption.
- Thought to blunt certain gluten-triggered barrier disruption.
Researched uses
- Celiac-disease adjunct research
- Intestinal-permeability (leaky gut) studies
- Gut-barrier and inflammation models
- Mucosal-integrity investigations
Commonly cited protocol
| Typical dose | Commonly cited around 0.5 mg (500 mcg) before meals in trials |
|---|---|
| Frequency | Typically three times daily with meals |
| Route | Oral |
| Notes | Designed to act in the gut; taken by mouth. |
Reconstitution
Administered orally and acts within the gut lumen, so injection reconstitution and syringe unit math do not apply.
Cautions
- Investigational; not FDA-approved.
- Efficacy data remain mixed in later trials.
- Intended to act locally, not as a systemic agent.
- Educational context only, not a treatment recommendation.
Larazotide FAQ
What is Larazotide?
An orally administered, locally acting gut-barrier peptide commonly cited in the research literature for context on intestinal permeability.
How does Larazotide work?
Appears to promote assembly of intestinal tight junctions. May reduce paracellular permeability of the gut lining. Acts locally in the intestinal lumen with minimal systemic absorption. Thought to blunt certain gluten-triggered barrier disruption.
What is Larazotide used for?
Celiac-disease adjunct research; Intestinal-permeability (leaky gut) studies; Gut-barrier and inflammation models; Mucosal-integrity investigations.
What is a typical Larazotide dose?
Commonly cited around 0.5 mg (500 mcg) before meals in trials, Typically three times daily with meals, Oral. This is a commonly cited figure for context only, not medical advice.
How do you reconstitute Larazotide?
Administered orally and acts within the gut lumen, so injection reconstitution and syringe unit math do not apply.
What is the half-life of Larazotide?
Not applicable in the usual systemic sense - it acts locally and is minimally absorbed.