KPV
Also known as: Lysine-Proline-Valine
A tiny tripeptide fragment of α-MSH studied for its anti-inflammatory effects, especially in the gut.
KPV at a glance
| Name | KPV |
|---|---|
| Also known as | Lysine-Proline-Valine |
| Category | Gut & anti-inflammatory |
| Type | Peptide |
| Sequence | Lys-Pro-Val (a fragment of α-MSH) |
| Typical dose | ~200–500 mcg |
| Frequency | Daily |
| Route | Oral (gut-local) or subcutaneous injection |
| Half-life | Short. |
Overview
KPV is the tail end of the α-MSH hormone, and it carries much of that hormone’s anti-inflammatory punch without the pigmentation effects. It is studied for inflammatory bowel conditions, wound healing, and skin inflammation, and is often used orally for gut-local effects.
How it’s thought to work
- Reduces pro-inflammatory signaling (NF-κB pathway) inside cells.
- Acts locally in the gut and on immune cells to calm inflammation.
Researched uses
- Gut inflammation (IBD models)
- Wound healing and skin inflammation
Commonly cited protocol
| Typical dose | ~200–500 mcg |
|---|---|
| Frequency | Daily |
| Route | Oral (gut-local) or subcutaneous injection |
| Notes | Often taken orally when the target is the gut. |
Reconstitution
Often a 5 mg vial. 5 mg with 2 mL water = 2.5 mg/mL, so 250 mcg = 10 units on a U-100 syringe.
KPV dosage calculator
The calculator below is pre-filled with KPV’s commonly cited vial size and dose. Adjust the vial amount, bacteriostatic water, or dose to match your own vial — it will show the exact insulin-syringe units to draw, the concentration, and how many doses the vial holds.
Add 2 mL of bacteriostatic water to your 5 mg vial. That gives you about 20 doses of 250 mcg. For each dose, draw 10 units into a 100-unit insulin syringe.
See the full KPV dosing chart (units for every dose & water amount), or open the full peptide calculator →
Cautions
- Not approved for human use.
- Limited human clinical data.
- Research chemical status.
KPV FAQ
What is KPV?
A tiny tripeptide fragment of α-MSH studied for its anti-inflammatory effects, especially in the gut.
How does KPV work?
Reduces pro-inflammatory signaling (NF-κB pathway) inside cells. Acts locally in the gut and on immune cells to calm inflammation.
What is KPV used for?
Gut inflammation (IBD models); Wound healing and skin inflammation.
What is a typical KPV dose?
~200–500 mcg, Daily, Oral (gut-local) or subcutaneous injection. This is a commonly cited figure for context only, not medical advice.
How do you reconstitute KPV?
Often a 5 mg vial. 5 mg with 2 mL water = 2.5 mg/mL, so 250 mcg = 10 units on a U-100 syringe.
What is the half-life of KPV?
Short.