MGF (Mechano Growth Factor)
Also known as: Mechano Growth Factor · IGF-1Ec splice variant
A splice variant of IGF-1 produced in muscle in response to mechanical stress, studied for its role in muscle repair and satellite-cell activation.
MGF (Mechano Growth Factor) at a glance
| Name | MGF (Mechano Growth Factor) |
|---|---|
| Also known as | Mechano Growth Factor, IGF-1Ec splice variant |
| Category | Growth & muscle |
| Type | Peptide |
| Sequence | IGF-1Ec splice variant (C-terminal E-domain peptide of mechano growth factor) |
| Typical dose | ~100-200 mcg per dose |
| Frequency | Often cited around training in research discussions |
| Route | Subcutaneous injection (research) |
| Half-life | Very short - on the order of minutes for the native peptide. |
Overview
MGF is a naturally occurring splice variant of IGF-1 that muscle tissue expresses after mechanical loading or damage. Research suggests it plays an early role in activating muscle stem (satellite) cells and initiating repair before the effects of systemic IGF-1 take over. Synthetic MGF has been used as a research tool to study these processes. Native MGF is short-acting, and it is not an approved therapeutic.
How it’s thought to work
- Appears to activate muscle satellite cells, supporting repair after mechanical stress.
- Thought to act through a distinct pathway from mature IGF-1 in early repair.
- May help delay differentiation so more precursor cells are available for growth.
- Signals locally in muscle tissue rather than acting as a systemic hormone.
Researched uses
- Muscle repair and satellite-cell research
- Studies of exercise-induced muscle adaptation
- Investigating IGF-1 splice-variant signaling
Commonly cited protocol
| Typical dose | ~100-200 mcg per dose |
|---|---|
| Frequency | Often cited around training in research discussions |
| Route | Subcutaneous injection (research) |
| Notes | Native MGF is short-lived, which motivated development of the pegylated PEG-MGF form. |
Reconstitution
Commonly supplied as a 2 mg lyophilized vial. Reconstituting 2 mg with 2 mL of bacteriostatic water gives 1 mg/mL, so a 100 mcg dose is about 10 units on a U-100 syringe.
MGF (Mechano Growth Factor) dosage calculator
The calculator below is pre-filled with MGF (Mechano Growth Factor)’s commonly cited vial size and dose. Adjust the vial amount, bacteriostatic water, or dose to match your own vial — it will show the exact insulin-syringe units to draw, the concentration, and how many doses the vial holds.
Add 2 mL of bacteriostatic water to your 2 mg vial. That gives you about 20 doses of 100 mcg. For each dose, draw 10 units into a 100-unit insulin syringe.
See the full MGF (Mechano Growth Factor) dosing chart (units for every dose & water amount), or open the full peptide calculator →
Cautions
- A research chemical not approved by the FDA for human use; prohibited in sport.
- Human efficacy and safety data are very limited.
- IGF-related signaling raises theoretical growth-related concerns.
- Research-grade purity varies by source.
MGF (Mechano Growth Factor) FAQ
What is MGF (Mechano Growth Factor)?
A splice variant of IGF-1 produced in muscle in response to mechanical stress, studied for its role in muscle repair and satellite-cell activation.
How does MGF (Mechano Growth Factor) work?
Appears to activate muscle satellite cells, supporting repair after mechanical stress. Thought to act through a distinct pathway from mature IGF-1 in early repair. May help delay differentiation so more precursor cells are available for growth. Signals locally in muscle tissue rather than acting as a systemic hormone.
What is MGF (Mechano Growth Factor) used for?
Muscle repair and satellite-cell research; Studies of exercise-induced muscle adaptation; Investigating IGF-1 splice-variant signaling.
What is a typical MGF (Mechano Growth Factor) dose?
~100-200 mcg per dose, Often cited around training in research discussions, Subcutaneous injection (research). This is a commonly cited figure for context only, not medical advice.
How do you reconstitute MGF (Mechano Growth Factor)?
Commonly supplied as a 2 mg lyophilized vial. Reconstituting 2 mg with 2 mL of bacteriostatic water gives 1 mg/mL, so a 100 mcg dose is about 10 units on a U-100 syringe.
What is the half-life of MGF (Mechano Growth Factor)?
Very short - on the order of minutes for the native peptide.