PEG-MGF
Also known as: Pegylated MGF · Pegylated Mechano Growth Factor
A pegylated version of mechano growth factor engineered for a longer half-life, studied for muscle repair and satellite-cell activation over a more sustained window.
PEG-MGF at a glance
| Name | PEG-MGF |
|---|---|
| Also known as | Pegylated MGF, Pegylated Mechano Growth Factor |
| Category | Growth & muscle |
| Type | Peptide |
| Sequence | Pegylated form of MGF (IGF-1Ec splice-variant peptide with attached PEG group) |
| Typical dose | ~200-400 mcg per dose |
| Frequency | Two to three times weekly in research discussions |
| Route | Subcutaneous injection (research) |
| Half-life | Extended relative to native MGF - estimated on the order of hours to a day. |
Overview
PEG-MGF is mechano growth factor modified by attaching polyethylene glycol (PEG) to slow its breakdown. Because native MGF is cleared within minutes, this modification aims to extend its presence in circulation so it can act over hours rather than minutes. Research interest parallels that of MGF, focusing on muscle repair and satellite-cell activation. It is an investigational compound and is not approved for human use.
How it’s thought to work
- Retains MGF's proposed role in activating muscle satellite cells.
- PEGylation is intended to slow enzymatic degradation and prolong action.
- Thought to support early muscle repair signaling over an extended window.
- Acts through IGF-1 splice-variant pathways rather than as systemic IGF-1.
Researched uses
- Muscle repair and recovery research
- Studies extending MGF activity beyond its natural short window
- Investigating satellite-cell activation after exercise
Commonly cited protocol
| Typical dose | ~200-400 mcg per dose |
|---|---|
| Frequency | Two to three times weekly in research discussions |
| Route | Subcutaneous injection (research) |
| Notes | Less frequent dosing than native MGF is cited because of the extended half-life. |
Reconstitution
Commonly supplied as a 2 mg lyophilized vial. Reconstituting 2 mg with 2 mL of bacteriostatic water gives 1 mg/mL, so a 200 mcg dose is about 20 units on a U-100 syringe.
PEG-MGF dosage calculator
The calculator below is pre-filled with PEG-MGF’s commonly cited vial size and dose. Adjust the vial amount, bacteriostatic water, or dose to match your own vial — it will show the exact insulin-syringe units to draw, the concentration, and how many doses the vial holds.
Add 2 mL of bacteriostatic water to your 2 mg vial. That gives you about 10 doses of 200 mcg. For each dose, draw 20 units into a 100-unit insulin syringe.
See the full PEG-MGF dosing chart (units for every dose & water amount), or open the full peptide calculator →
Cautions
- A research chemical not approved by the FDA for human use; prohibited in sport.
- Human safety and efficacy data are very limited.
- IGF-related signaling raises theoretical growth-related concerns.
- Research-grade purity varies by source.
PEG-MGF FAQ
What is PEG-MGF?
A pegylated version of mechano growth factor engineered for a longer half-life, studied for muscle repair and satellite-cell activation over a more sustained window.
How does PEG-MGF work?
Retains MGF's proposed role in activating muscle satellite cells. PEGylation is intended to slow enzymatic degradation and prolong action. Thought to support early muscle repair signaling over an extended window. Acts through IGF-1 splice-variant pathways rather than as systemic IGF-1.
What is PEG-MGF used for?
Muscle repair and recovery research; Studies extending MGF activity beyond its natural short window; Investigating satellite-cell activation after exercise.
What is a typical PEG-MGF dose?
~200-400 mcg per dose, Two to three times weekly in research discussions, Subcutaneous injection (research). This is a commonly cited figure for context only, not medical advice.
How do you reconstitute PEG-MGF?
Commonly supplied as a 2 mg lyophilized vial. Reconstituting 2 mg with 2 mL of bacteriostatic water gives 1 mg/mL, so a 200 mcg dose is about 20 units on a U-100 syringe.
What is the half-life of PEG-MGF?
Extended relative to native MGF - estimated on the order of hours to a day.