IGF-1 LR3
Also known as: Long R3 IGF-1
A long-acting analog of insulin-like growth factor 1, studied for muscle growth and recovery.
IGF-1 LR3 at a glance
| Name | IGF-1 LR3 |
|---|---|
| Also known as | Long R3 IGF-1 |
| Category | Growth & muscle |
| Type | Peptide |
| Sequence | IGF-1 with an Arg3 substitution and a 13-amino-acid N-terminal extension |
| Typical dose | ~20–50 mcg |
| Frequency | Daily in research contexts |
| Route | Subcutaneous injection |
| Half-life | Extended vs native IGF-1 (hours). |
Overview
IGF-1 LR3 is a modified, longer-lasting version of IGF-1 — the downstream hormone through which growth hormone drives much of its muscle-building and repair effects. The modifications reduce its binding to carrier proteins, so more stays active for longer.
How it’s thought to work
- Activates IGF-1 receptors to promote cell growth, protein synthesis, and repair.
- Reduced binding-protein affinity extends its active window vs native IGF-1.
Researched uses
- Muscle growth and hyperplasia research
- Recovery and tissue repair
Commonly cited protocol
| Typical dose | ~20–50 mcg |
|---|---|
| Frequency | Daily in research contexts |
| Route | Subcutaneous injection |
| Notes | Often timed around training in anecdotal use. |
Reconstitution
Often a 1 mg vial. 1 mg with 1 mL water = 1 mg/mL, so 50 mcg = 5 units on a U-100 syringe.
IGF-1 LR3 dosage calculator
The calculator below is pre-filled with IGF-1 LR3’s commonly cited vial size and dose. Adjust the vial amount, bacteriostatic water, or dose to match your own vial — it will show the exact insulin-syringe units to draw, the concentration, and how many doses the vial holds.
Add 1 mL of bacteriostatic water to your 1 mg vial. That gives you about 20 doses of 50 mcg. For each dose, draw 5 units into a 100-unit insulin syringe.
See the full IGF-1 LR3 dosing chart (units for every dose & water amount), or open the full peptide calculator →
Cautions
- Not approved for human use.
- Can lower blood sugar (hypoglycemia risk).
- Pro-growth signaling — significant caution with any cancer risk.
IGF-1 LR3 FAQ
What is IGF-1 LR3?
A long-acting analog of insulin-like growth factor 1, studied for muscle growth and recovery.
How does IGF-1 LR3 work?
Activates IGF-1 receptors to promote cell growth, protein synthesis, and repair. Reduced binding-protein affinity extends its active window vs native IGF-1.
What is IGF-1 LR3 used for?
Muscle growth and hyperplasia research; Recovery and tissue repair.
What is a typical IGF-1 LR3 dose?
~20–50 mcg, Daily in research contexts, Subcutaneous injection. This is a commonly cited figure for context only, not medical advice.
How do you reconstitute IGF-1 LR3?
Often a 1 mg vial. 1 mg with 1 mL water = 1 mg/mL, so 50 mcg = 5 units on a U-100 syringe.
What is the half-life of IGF-1 LR3?
Extended vs native IGF-1 (hours).