SS-31
Also known as: Elamipretide · MTP-131
A mitochondria-targeting peptide studied for cellular energy, recovery, and age-related decline.
SS-31 at a glance
| Name | SS-31 |
|---|---|
| Also known as | Elamipretide, MTP-131 |
| Category | Mitochondrial & longevity |
| Type | Peptide |
| Sequence | Cell-permeable tetrapeptide that concentrates in mitochondria |
| Typical dose | ~5–10 mg |
| Frequency | Daily in research/clinical trials |
| Route | Subcutaneous injection |
| Half-life | Short. |
Overview
SS-31 (elamipretide) homes in on the inner mitochondrial membrane, where it stabilizes cardiolipin — a lipid essential for efficient energy production. Research has explored it for heart, muscle, kidney, and eye conditions tied to failing mitochondria, as well as general recovery.
How it’s thought to work
- Binds cardiolipin to stabilize the mitochondrial membrane and electron transport.
- Improves ATP production and reduces mitochondrial reactive oxygen species.
Researched uses
- Mitochondrial dysfunction and fatigue research
- Cardiac, muscle, and recovery studies
Commonly cited protocol
| Typical dose | ~5–10 mg |
|---|---|
| Frequency | Daily in research/clinical trials |
| Route | Subcutaneous injection |
| Notes | Trial dosing varies by indication. |
Reconstitution
Often a 50 mg vial. 50 mg with 5 mL water = 10 mg/mL, so 5 mg = 50 units on a U-100 syringe.
SS-31 dosage calculator
The calculator below is pre-filled with SS-31’s commonly cited vial size and dose. Adjust the vial amount, bacteriostatic water, or dose to match your own vial — it will show the exact insulin-syringe units to draw, the concentration, and how many doses the vial holds.
Add 5 mL of bacteriostatic water to your 50 mg vial. That gives you about 10 doses of 5 mg. For each dose, draw 50 units into a 100-unit insulin syringe.
See the full SS-31 dosing chart (units for every dose & water amount), or open the full peptide calculator →
Cautions
- Investigational; not broadly approved.
- Injection-site reactions reported in trials.
- Long-term safety still being studied.
SS-31 FAQ
What is SS-31?
A mitochondria-targeting peptide studied for cellular energy, recovery, and age-related decline.
How does SS-31 work?
Binds cardiolipin to stabilize the mitochondrial membrane and electron transport. Improves ATP production and reduces mitochondrial reactive oxygen species.
What is SS-31 used for?
Mitochondrial dysfunction and fatigue research; Cardiac, muscle, and recovery studies.
What is a typical SS-31 dose?
~5–10 mg, Daily in research/clinical trials, Subcutaneous injection. This is a commonly cited figure for context only, not medical advice.
How do you reconstitute SS-31?
Often a 50 mg vial. 50 mg with 5 mL water = 10 mg/mL, so 5 mg = 50 units on a U-100 syringe.
What is the half-life of SS-31?
Short.