Argireline (Acetyl Hexapeptide-8)
Also known as: Acetyl Hexapeptide-3 · Acetyl Hexapeptide-8
A topical cosmetic peptide studied for the appearance of expression lines.
Argireline (Acetyl Hexapeptide-8) at a glance
| Name | Argireline (Acetyl Hexapeptide-8) |
|---|---|
| Also known as | Acetyl Hexapeptide-3, Acetyl Hexapeptide-8 |
| Category | Skin & cosmetic |
| Type | Peptide |
| Sequence | Acetylated hexapeptide (N-terminally acetylated, amidated). |
| Typical dose | Commonly formulated around 5-10% in leave-on cosmetics |
| Frequency | Typically applied once or twice daily |
| Route | Topical |
| Half-life | Not typically characterized for topical cosmetic use. |
Overview
Argireline is a synthetic hexapeptide used in leave-on cosmetic formulations. It is marketed for the look of fine expression lines around the eyes and forehead. Evidence comes largely from manufacturer and small topical studies; it is a cosmetic ingredient rather than a medical treatment.
How it’s thought to work
- Proposed to interfere with components of the neurotransmitter-release complex in skin.
- Marketed to reduce the appearance of repeated facial-muscle movement.
- Acts at the level of the skin surface as a cosmetic conditioning agent.
Researched uses
- Appearance of forehead and periorbital expression lines
- Cosmetic anti-aging formulations
- Topical skin-smoothing serums and creams
Commonly cited protocol
| Typical dose | Commonly formulated around 5-10% in leave-on cosmetics |
|---|---|
| Frequency | Typically applied once or twice daily |
| Route | Topical |
| Notes | Applied to clean skin as part of a serum or cream; a cosmetic, not an injectable. |
Reconstitution
Not applicable - this is a topical cosmetic ingredient, so injection unit math does not apply.
Cautions
- A cosmetic ingredient, not a medical treatment.
- Evidence for wrinkle reduction is limited and largely industry-sourced.
- May cause local irritation in sensitive individuals; patch testing is common.
Argireline (Acetyl Hexapeptide-8) FAQ
What is Argireline (Acetyl Hexapeptide-8)?
A topical cosmetic peptide studied for the appearance of expression lines.
How does Argireline (Acetyl Hexapeptide-8) work?
Proposed to interfere with components of the neurotransmitter-release complex in skin. Marketed to reduce the appearance of repeated facial-muscle movement. Acts at the level of the skin surface as a cosmetic conditioning agent.
What is Argireline (Acetyl Hexapeptide-8) used for?
Appearance of forehead and periorbital expression lines; Cosmetic anti-aging formulations; Topical skin-smoothing serums and creams.
What is a typical Argireline (Acetyl Hexapeptide-8) dose?
Commonly formulated around 5-10% in leave-on cosmetics, Typically applied once or twice daily, Topical. This is a commonly cited figure for context only, not medical advice.
How do you reconstitute Argireline (Acetyl Hexapeptide-8)?
Not applicable - this is a topical cosmetic ingredient, so injection unit math does not apply.
What is the half-life of Argireline (Acetyl Hexapeptide-8)?
Not typically characterized for topical cosmetic use.