Matrixyl (Palmitoyl Pentapeptide-4)
Also known as: Palmitoyl Pentapeptide-4 · Pal-KTTKS
A topical cosmetic peptide studied for collagen-related skin appearance.
Matrixyl (Palmitoyl Pentapeptide-4) at a glance
| Name | Matrixyl (Palmitoyl Pentapeptide-4) |
|---|---|
| Also known as | Palmitoyl Pentapeptide-4, Pal-KTTKS |
| Category | Skin & cosmetic |
| Type | Peptide |
| Sequence | Palmitoylated pentapeptide (palmitoyl-Lys-Thr-Thr-Lys-Ser). |
| Typical dose | Often formulated around 3-8% of a matrix concentrate in leave-on products |
| Frequency | Typically applied once or twice daily |
| Route | Topical |
| Half-life | Not typically characterized for topical cosmetic use. |
Overview
Matrixyl is a lipidated pentapeptide used in leave-on skincare. It is marketed to support the appearance of firmer, smoother skin. The palmitoyl chain is intended to aid skin penetration. It is a cosmetic ingredient, not a medical therapy.
How it’s thought to work
- Proposed to signal fibroblasts to support collagen-related activity.
- The palmitoyl group is intended to improve delivery through the skin barrier.
- Acts as a cosmetic conditioning agent at the skin surface.
Researched uses
- Appearance of fine lines and skin firmness
- Cosmetic anti-aging serums and moisturizers
- Formulations targeting skin texture
Commonly cited protocol
| Typical dose | Often formulated around 3-8% of a matrix concentrate in leave-on products |
|---|---|
| Frequency | Typically applied once or twice daily |
| Route | Topical |
| Notes | Blended into serums or creams; not used by injection. |
Reconstitution
Not applicable - this is a topical cosmetic ingredient, so injection unit math does not apply.
Cautions
- A cosmetic ingredient, not a medical treatment.
- Clinical evidence is limited and often manufacturer-sponsored.
- May cause irritation in sensitive skin; patch testing is common.
Matrixyl (Palmitoyl Pentapeptide-4) FAQ
What is Matrixyl (Palmitoyl Pentapeptide-4)?
A topical cosmetic peptide studied for collagen-related skin appearance.
How does Matrixyl (Palmitoyl Pentapeptide-4) work?
Proposed to signal fibroblasts to support collagen-related activity. The palmitoyl group is intended to improve delivery through the skin barrier. Acts as a cosmetic conditioning agent at the skin surface.
What is Matrixyl (Palmitoyl Pentapeptide-4) used for?
Appearance of fine lines and skin firmness; Cosmetic anti-aging serums and moisturizers; Formulations targeting skin texture.
What is a typical Matrixyl (Palmitoyl Pentapeptide-4) dose?
Often formulated around 3-8% of a matrix concentrate in leave-on products, Typically applied once or twice daily, Topical. This is a commonly cited figure for context only, not medical advice.
How do you reconstitute Matrixyl (Palmitoyl Pentapeptide-4)?
Not applicable - this is a topical cosmetic ingredient, so injection unit math does not apply.
What is the half-life of Matrixyl (Palmitoyl Pentapeptide-4)?
Not typically characterized for topical cosmetic use.