Cortagen
Also known as: Cortagen bioregulator · Cortical peptide
A short peptide bioregulator from Russian research, studied for effects on brain cortex tissue and neural function.
Cortagen at a glance
| Name | Cortagen |
|---|---|
| Also known as | Cortagen bioregulator, Cortical peptide |
| Category | Cognitive & neuroprotective |
| Type | Peptide |
| Sequence | Ala-Glu-Asp-Pro |
| Typical dose | ~2-4 mg per day |
| Frequency | Once daily over short courses in reported use |
| Route | Intramuscular injection (research) |
| Half-life | Very short; rapidly cleared. |
Overview
Cortagen is a short synthetic peptide bioregulator developed within Khavinson's program and associated with the brain cortex. It is commonly cited in the Russian research literature for context on neuroprotection and recovery of nerve function. As with the other bioregulators, human evidence is limited, largely non-Western, and not widely replicated by independent groups.
How it’s thought to work
- Proposed to act as a tissue-specific peptide bioregulator for neural tissue.
- Reported to influence nerve regeneration in animal studies.
- Suggested to modulate gene expression relevant to brain cells.
- Described as supporting antioxidant and neurotrophic processes.
Researched uses
- Peripheral nerve recovery in animal research
- Neuroprotection studies
- Cognitive and neural function research
- Recovery after neural injury (preclinical)
Commonly cited protocol
| Typical dose | ~2-4 mg per day |
|---|---|
| Frequency | Once daily over short courses in reported use |
| Route | Intramuscular injection (research) |
| Notes | Provided as a lyophilized powder in original formulations. |
Reconstitution
Commonly a 5 mg vial; 5 mg in 2 mL gives 2.5 mg/mL, so a 2 mg dose is about 16 units on a U-100 syringe.
Cortagen dosage calculator
The calculator below is pre-filled with Cortagen’s commonly cited vial size and dose. Adjust the vial amount, bacteriostatic water, or dose to match your own vial — it will show the exact insulin-syringe units to draw, the concentration, and how many doses the vial holds.
Add 2 mL of bacteriostatic water to your 5 mg vial. That gives you about 2 doses of 2000 mcg. For each dose, draw 80 units into a 100-unit insulin syringe.
See the full Cortagen dosing chart (units for every dose & water amount), or open the full peptide calculator →
Cautions
- Not FDA-approved; a research chemical outside its origin countries.
- Human evidence is limited and largely non-Western.
- Long-term safety is not established.
- Source purity and identity vary.
Cortagen FAQ
What is Cortagen?
A short peptide bioregulator from Russian research, studied for effects on brain cortex tissue and neural function.
How does Cortagen work?
Proposed to act as a tissue-specific peptide bioregulator for neural tissue. Reported to influence nerve regeneration in animal studies. Suggested to modulate gene expression relevant to brain cells. Described as supporting antioxidant and neurotrophic processes.
What is Cortagen used for?
Peripheral nerve recovery in animal research; Neuroprotection studies; Cognitive and neural function research; Recovery after neural injury (preclinical).
What is a typical Cortagen dose?
~2-4 mg per day, Once daily over short courses in reported use, Intramuscular injection (research). This is a commonly cited figure for context only, not medical advice.
How do you reconstitute Cortagen?
Commonly a 5 mg vial; 5 mg in 2 mL gives 2.5 mg/mL, so a 2 mg dose is about 16 units on a U-100 syringe.
What is the half-life of Cortagen?
Very short; rapidly cleared.