Mazdutide
Also known as: IBI362 · LY3305677
An investigational GLP-1/glucagon dual receptor agonist studied in the literature for metabolic and body-weight endpoints.
Mazdutide at a glance
| Name | Mazdutide |
|---|---|
| Also known as | IBI362, LY3305677 |
| Category | Metabolic & weight |
| Type | Peptide |
| Sequence | GLP-1/glucagon dual receptor agonist analog (oxyntomodulin-based) |
| Typical dose | ~3-9 mg once weekly has been cited in reported trials; not an established or approved regimen |
| Frequency | Commonly cited as once weekly in study designs |
| Route | Subcutaneous injection (investigational / research) |
| Half-life | Reported to support once-weekly dosing; precise human values are not firmly established. |
Overview
Mazdutide is an investigational peptide designed to activate both the GLP-1 and glucagon receptors, an approach based on the oxyntomodulin backbone. It has been evaluated in clinical trials but is not an approved medicine, and it appears here only for educational context.
How it’s thought to work
- Reported to co-activate GLP-1 and glucagon receptors.
- GLP-1 activity is commonly cited as supporting glucose-dependent insulin secretion and appetite reduction.
- Glucagon-receptor activity is described in the literature as potentially increasing energy expenditure.
- The dual approach is studied for combined effects on glucose and body weight.
Researched uses
- Body-weight reduction in clinical trial populations
- Glycemic control endpoints in type 2 diabetes studies
- Explored in the literature for effects on hepatic fat
Commonly cited protocol
| Typical dose | ~3-9 mg once weekly has been cited in reported trials; not an established or approved regimen |
|---|---|
| Frequency | Commonly cited as once weekly in study designs |
| Route | Subcutaneous injection (investigational / research) |
| Notes | Investigational compound; figures reflect reported trial ranges, not clinical guidance. |
Reconstitution
If supplied as a lyophilized research vial, reconstituting 10 mg with 2 mL bacteriostatic water gives 5 mg/mL, so 1 mg would be about 20 units on a U-100 syringe. Figures are illustrative only.
Mazdutide dosage calculator
The calculator below is pre-filled with Mazdutide’s commonly cited vial size and dose. Adjust the vial amount, bacteriostatic water, or dose to match your own vial — it will show the exact insulin-syringe units to draw, the concentration, and how many doses the vial holds.
Add 2 mL of bacteriostatic water to your 10 mg vial. That gives you about 10 doses of 1 mg. For each dose, draw 20 units into a 100-unit insulin syringe.
See the full Mazdutide dosing chart (units for every dose & water amount), or open the full peptide calculator →
Cautions
- Investigational research compound; not FDA-approved for any use.
- Human safety and long-term data remain limited.
- Research-grade material purity varies by source.
- Educational context only and not a recommendation to use.
Mazdutide FAQ
What is Mazdutide?
An investigational GLP-1/glucagon dual receptor agonist studied in the literature for metabolic and body-weight endpoints.
How does Mazdutide work?
Reported to co-activate GLP-1 and glucagon receptors. GLP-1 activity is commonly cited as supporting glucose-dependent insulin secretion and appetite reduction. Glucagon-receptor activity is described in the literature as potentially increasing energy expenditure. The dual approach is studied for combined effects on glucose and body weight.
What is Mazdutide used for?
Body-weight reduction in clinical trial populations; Glycemic control endpoints in type 2 diabetes studies; Explored in the literature for effects on hepatic fat.
What is a typical Mazdutide dose?
~3-9 mg once weekly has been cited in reported trials; not an established or approved regimen, Commonly cited as once weekly in study designs, Subcutaneous injection (investigational / research). This is a commonly cited figure for context only, not medical advice.
How do you reconstitute Mazdutide?
If supplied as a lyophilized research vial, reconstituting 10 mg with 2 mL bacteriostatic water gives 5 mg/mL, so 1 mg would be about 20 units on a U-100 syringe. Figures are illustrative only.
What is the half-life of Mazdutide?
Reported to support once-weekly dosing; precise human values are not firmly established.