Cagrilintide
Also known as: AM833
A long-acting amylin analog studied for weight loss, often paired with a GLP-1 agonist.
Cagrilintide at a glance
| Name | Cagrilintide |
|---|---|
| Also known as | AM833 |
| Category | Metabolic & weight |
| Type | Peptide |
| Sequence | Long-acting amylin receptor agonist |
| Typical dose | Titrated; up to ~2.4 mg weekly in trials |
| Frequency | Once weekly |
| Route | Subcutaneous injection |
| Half-life | Long — once-weekly dosing. |
Overview
Cagrilintide mimics amylin, a hormone that works alongside insulin to control appetite and slow digestion. It is investigational for weight management and has shown strong results combined with a GLP-1 agonist.
How it’s thought to work
- Activates amylin and calcitonin receptors to increase fullness and slow gastric emptying.
- Complements GLP-1 agonists via a separate appetite pathway.
Researched uses
- Weight management (investigational)
- Combination therapy with GLP-1 agonists
Commonly cited protocol
| Typical dose | Titrated; up to ~2.4 mg weekly in trials |
|---|---|
| Frequency | Once weekly |
| Route | Subcutaneous injection |
| Notes | Trial dosing; not an approved regimen. |
Reconstitution
Often a 5 mg vial. 5 mg with 2 mL water = 2.5 mg/mL, so 300 mcg = 12 units on a U-100 syringe.
Cagrilintide dosage calculator
The calculator below is pre-filled with Cagrilintide’s commonly cited vial size and dose. Adjust the vial amount, bacteriostatic water, or dose to match your own vial — it will show the exact insulin-syringe units to draw, the concentration, and how many doses the vial holds.
Add 2 mL of bacteriostatic water to your 5 mg vial. That gives you about 16 doses of 300 mcg. For each dose, draw 12 units into a 100-unit insulin syringe.
See the full Cagrilintide dosing chart (units for every dose & water amount), or open the full peptide calculator →
Cautions
- Not approved — still investigational.
- GI side effects similar to other weight-loss agents.
- Medical supervision essential.
Cagrilintide FAQ
What is Cagrilintide?
A long-acting amylin analog studied for weight loss, often paired with a GLP-1 agonist.
How does Cagrilintide work?
Activates amylin and calcitonin receptors to increase fullness and slow gastric emptying. Complements GLP-1 agonists via a separate appetite pathway.
What is Cagrilintide used for?
Weight management (investigational); Combination therapy with GLP-1 agonists.
What is a typical Cagrilintide dose?
Titrated; up to ~2.4 mg weekly in trials, Once weekly, Subcutaneous injection. This is a commonly cited figure for context only, not medical advice.
How do you reconstitute Cagrilintide?
Often a 5 mg vial. 5 mg with 2 mL water = 2.5 mg/mL, so 300 mcg = 12 units on a U-100 syringe.
What is the half-life of Cagrilintide?
Long — once-weekly dosing.