Retatrutide
Also known as: Triple-G · LY3437943
An investigational triple agonist (GLP-1 / GIP / glucagon) showing large weight-loss effects in trials.
Retatrutide at a glance
| Name | Retatrutide |
|---|---|
| Also known as | Triple-G, LY3437943 |
| Category | Metabolic & weight |
| Type | Peptide |
| Sequence | Triple GIP/GLP-1/glucagon receptor agonist |
| Typical dose | Titrated in trials (up to ~12 mg weekly) |
| Frequency | Once weekly |
| Route | Subcutaneous injection |
| Half-life | Long — once-weekly dosing. |
Overview
Retatrutide is an investigational “triple agonist” that adds glucagon-receptor activity on top of GIP and GLP-1. Early-phase trials reported some of the largest weight reductions yet for this drug class. It is not approved — it is still in clinical development.
How it’s thought to work
- Agonizes GLP-1, GIP, and glucagon receptors together.
- Combines appetite suppression and improved glucose handling with increased energy expenditure.
Researched uses
- Obesity (investigational)
- Type-2 diabetes and metabolic research
Commonly cited protocol
| Typical dose | Titrated in trials (up to ~12 mg weekly) |
|---|---|
| Frequency | Once weekly |
| Route | Subcutaneous injection |
| Notes | Dosing comes from clinical trials; not an approved regimen. |
Reconstitution
Research vials are commonly 10 mg; 10 mg with 2 mL water = 5 mg/mL, so 2 mg = 40 units on a U-100 syringe.
Retatrutide dosage calculator
The calculator below is pre-filled with Retatrutide’s commonly cited vial size and dose. Adjust the vial amount, bacteriostatic water, or dose to match your own vial — it will show the exact insulin-syringe units to draw, the concentration, and how many doses the vial holds.
Add 2 mL of bacteriostatic water to your 10 mg vial. That gives you about 5 doses of 2 mg. For each dose, draw 40 units into a 100-unit insulin syringe.
See the full Retatrutide dosing chart (units for every dose & water amount), or open the full peptide calculator →
Cautions
- Not approved — still investigational.
- GI side effects; may raise heart rate.
- Long-term safety unknown; medical supervision essential.
Retatrutide FAQ
What is Retatrutide?
An investigational triple agonist (GLP-1 / GIP / glucagon) showing large weight-loss effects in trials.
How does Retatrutide work?
Agonizes GLP-1, GIP, and glucagon receptors together. Combines appetite suppression and improved glucose handling with increased energy expenditure.
What is Retatrutide used for?
Obesity (investigational); Type-2 diabetes and metabolic research.
What is a typical Retatrutide dose?
Titrated in trials (up to ~12 mg weekly), Once weekly, Subcutaneous injection. This is a commonly cited figure for context only, not medical advice.
How do you reconstitute Retatrutide?
Research vials are commonly 10 mg; 10 mg with 2 mL water = 5 mg/mL, so 2 mg = 40 units on a U-100 syringe.
What is the half-life of Retatrutide?
Long — once-weekly dosing.