N-Acetyl Semax
Also known as: N-Acetyl Semax Amidate · NA-Semax
An acetylated analog of the Semax peptide, commonly cited in the research literature for context around cognition and neuroprotection.
N-Acetyl Semax at a glance
| Name | N-Acetyl Semax |
|---|---|
| Also known as | N-Acetyl Semax Amidate, NA-Semax |
| Category | Cognitive & neuroprotective |
| Type | Peptide |
| Sequence | N-acetylated analog of the ACTH(4-7) fragment Pro-Gly-Pro extension (heptapeptide derivative) |
| Typical dose | ~200-600 mcg per day (commonly cited) |
| Frequency | Once daily or split across the day |
| Route | Intranasal (research) |
| Half-life | Reported to be longer than unmodified Semax, still on the order of hours. |
Overview
N-Acetyl Semax is a chemically modified version of Semax, itself derived from a fragment of adrenocorticotropic hormone (ACTH). The acetyl modification is described in the literature as intended to improve metabolic stability. Most available data come from Russian preclinical and early clinical work; broad Western clinical trials are lacking. Presented here for educational context only, not as a recommendation to use.
How it’s thought to work
- Reported in research to influence brain-derived neurotrophic factor (BDNF) expression.
- Appears to modulate the melanocortin and ACTH-related signaling systems.
- Studied for possible effects on dopaminergic and serotonergic activity.
Researched uses
- Cognitive performance and attention in exploratory studies
- Neuroprotection in animal models of ischemia
- Mood and stress regulation in early research
Commonly cited protocol
| Typical dose | ~200-600 mcg per day (commonly cited) |
|---|---|
| Frequency | Once daily or split across the day |
| Route | Intranasal (research) |
| Notes | Typically applied as nasal drops or spray; the acetyl form is cited as longer-acting than plain Semax. |
Reconstitution
Usually supplied as a pre-mixed intranasal solution, so insulin-syringe injection unit math does not apply.
Cautions
- Not FDA-approved; sold as a research chemical in most markets.
- Human clinical evidence outside of Russian studies is limited.
- Purity and concentration vary widely by source.
- Not established as safe for general use.
N-Acetyl Semax FAQ
What is N-Acetyl Semax?
An acetylated analog of the Semax peptide, commonly cited in the research literature for context around cognition and neuroprotection.
How does N-Acetyl Semax work?
Reported in research to influence brain-derived neurotrophic factor (BDNF) expression. Appears to modulate the melanocortin and ACTH-related signaling systems. Studied for possible effects on dopaminergic and serotonergic activity.
What is N-Acetyl Semax used for?
Cognitive performance and attention in exploratory studies; Neuroprotection in animal models of ischemia; Mood and stress regulation in early research.
What is a typical N-Acetyl Semax dose?
~200-600 mcg per day (commonly cited), Once daily or split across the day, Intranasal (research). This is a commonly cited figure for context only, not medical advice.
How do you reconstitute N-Acetyl Semax?
Usually supplied as a pre-mixed intranasal solution, so insulin-syringe injection unit math does not apply.
What is the half-life of N-Acetyl Semax?
Reported to be longer than unmodified Semax, still on the order of hours.