PE-22-28
Also known as: Spadin analog · PE 22-28
A short peptide analog of spadin, commonly cited in the research literature for context around mood and neuroplasticity.
PE-22-28 at a glance
| Name | PE-22-28 |
|---|---|
| Also known as | Spadin analog, PE 22-28 |
| Category | Cognitive & neuroprotective |
| Type | Peptide |
| Sequence | Seven-residue analog of spadin, derived from the sortilin propeptide |
| Typical dose | ~200-600 mcg (figures extrapolated from animal work) |
| Frequency | Once daily in studies |
| Route | Subcutaneous injection (research) |
| Half-life | Reported to be short (minutes to a few hours). |
Overview
PE-22-28 is a truncated analog of spadin, a peptide fragment from the sortilin propeptide. It has been studied in animal models as a blocker of the TREK-1 potassium channel, a target linked to mood regulation. There is no established human use, and it is presented here for educational context only.
How it’s thought to work
- Reported to inhibit the TREK-1 (two-pore potassium) channel.
- Appears to promote hippocampal neurogenesis in models.
- Studied for rapid antidepressant-like effects in rodents.
Researched uses
- Depression-like behavior in animal models
- Neurogenesis and synaptic plasticity research
- Exploratory work on stroke and neuroprotection
Commonly cited protocol
| Typical dose | ~200-600 mcg (figures extrapolated from animal work) |
|---|---|
| Frequency | Once daily in studies |
| Route | Subcutaneous injection (research) |
| Notes | Human dosing is not established; some research used intranasal delivery. |
Reconstitution
For a 5 mg vial reconstituted with 2 mL, the concentration is 2.5 mg/mL, so a 250 mcg dose is about 10 units on a U-100 syringe.
PE-22-28 dosage calculator
The calculator below is pre-filled with PE-22-28’s commonly cited vial size and dose. Adjust the vial amount, bacteriostatic water, or dose to match your own vial — it will show the exact insulin-syringe units to draw, the concentration, and how many doses the vial holds.
Add 2 mL of bacteriostatic water to your 5 mg vial. That gives you about 20 doses of 250 mcg. For each dose, draw 10 units into a 100-unit insulin syringe.
See the full PE-22-28 dosing chart (units for every dose & water amount), or open the full peptide calculator →
Cautions
- Not FDA-approved; a research chemical.
- No human clinical evidence is available.
- Dosing is speculative and extrapolated.
- Purity varies by supplier.
PE-22-28 FAQ
What is PE-22-28?
A short peptide analog of spadin, commonly cited in the research literature for context around mood and neuroplasticity.
How does PE-22-28 work?
Reported to inhibit the TREK-1 (two-pore potassium) channel. Appears to promote hippocampal neurogenesis in models. Studied for rapid antidepressant-like effects in rodents.
What is PE-22-28 used for?
Depression-like behavior in animal models; Neurogenesis and synaptic plasticity research; Exploratory work on stroke and neuroprotection.
What is a typical PE-22-28 dose?
~200-600 mcg (figures extrapolated from animal work), Once daily in studies, Subcutaneous injection (research). This is a commonly cited figure for context only, not medical advice.
How do you reconstitute PE-22-28?
For a 5 mg vial reconstituted with 2 mL, the concentration is 2.5 mg/mL, so a 250 mcg dose is about 10 units on a U-100 syringe.
What is the half-life of PE-22-28?
Reported to be short (minutes to a few hours).