Survodutide
Also known as: BI 456906
An investigational dual glucagon/GLP-1 receptor agonist studied for weight loss and liver disease.
Survodutide at a glance
| Name | Survodutide |
|---|---|
| Also known as | BI 456906 |
| Category | Metabolic & weight |
| Type | Peptide |
| Sequence | Dual glucagon/GLP-1 receptor agonist |
| Typical dose | Titrated in trials |
| Frequency | Once weekly |
| Route | Subcutaneous injection |
| Half-life | Long — once-weekly dosing. |
Overview
Survodutide activates both the glucagon and GLP-1 receptors — combining appetite suppression with increased energy expenditure and liver-fat reduction. It is in clinical development for obesity and for MASH (fatty liver disease), where early results have been promising.
How it’s thought to work
- Dual agonist of glucagon and GLP-1 receptors.
- Reduces appetite while raising energy expenditure and lowering liver fat.
Researched uses
- Obesity (investigational)
- MASH / fatty-liver disease research
Commonly cited protocol
| Typical dose | Titrated in trials |
|---|---|
| Frequency | Once weekly |
| Route | Subcutaneous injection |
| Notes | Trial dosing; not an approved regimen. |
Reconstitution
Research vials commonly 10 mg. 10 mg with 2 mL water = 5 mg/mL, so 2 mg = 40 units on a U-100 syringe.
Survodutide dosage calculator
The calculator below is pre-filled with Survodutide’s commonly cited vial size and dose. Adjust the vial amount, bacteriostatic water, or dose to match your own vial — it will show the exact insulin-syringe units to draw, the concentration, and how many doses the vial holds.
Add 2 mL of bacteriostatic water to your 10 mg vial. That gives you about 5 doses of 2 mg. For each dose, draw 40 units into a 100-unit insulin syringe.
See the full Survodutide dosing chart (units for every dose & water amount), or open the full peptide calculator →
Cautions
- Not approved — still investigational.
- GI side effects; may raise heart rate.
- Medical supervision essential.
Survodutide FAQ
What is Survodutide?
An investigational dual glucagon/GLP-1 receptor agonist studied for weight loss and liver disease.
How does Survodutide work?
Dual agonist of glucagon and GLP-1 receptors. Reduces appetite while raising energy expenditure and lowering liver fat.
What is Survodutide used for?
Obesity (investigational); MASH / fatty-liver disease research.
What is a typical Survodutide dose?
Titrated in trials, Once weekly, Subcutaneous injection. This is a commonly cited figure for context only, not medical advice.
How do you reconstitute Survodutide?
Research vials commonly 10 mg. 10 mg with 2 mL water = 5 mg/mL, so 2 mg = 40 units on a U-100 syringe.
What is the half-life of Survodutide?
Long — once-weekly dosing.