Sermorelin
Also known as: GRF 1-29
A GHRH analog (the first 29 amino acids) that prompts the pituitary to release growth hormone.
Sermorelin at a glance
| Name | Sermorelin |
|---|---|
| Also known as | GRF 1-29 |
| Category | Growth-hormone axis |
| Type | Peptide |
| Sequence | GHRH(1-29) — the active fragment of growth-hormone-releasing hormone |
| Typical dose | ~200–300 mcg |
| Frequency | Nightly |
| Route | Subcutaneous injection |
| Half-life | Short (~10–20 minutes). |
Overview
Sermorelin is the 1–29 fragment of GHRH and one of the longest-studied GH secretagogues, historically used to test pituitary function and in anti-aging clinics. It nudges the body’s own GH production in a natural, pulsatile way rather than supplying GH directly.
How it’s thought to work
- Binds pituitary GHRH receptors to release endogenous GH.
- Preserves the body’s natural GH pulse and feedback.
Researched uses
- Raising endogenous GH/IGF-1
- Age-related GH decline research
- Sleep and recovery
Commonly cited protocol
| Typical dose | ~200–300 mcg |
|---|---|
| Frequency | Nightly |
| Route | Subcutaneous injection |
| Notes | Bedtime dosing aligns with the natural GH pulse. |
Reconstitution
Often a 5 mg vial. 5 mg with 2 mL water = 2.5 mg/mL, so 300 mcg = 12 units on a U-100 syringe.
Sermorelin dosage calculator
The calculator below is pre-filled with Sermorelin’s commonly cited vial size and dose. Adjust the vial amount, bacteriostatic water, or dose to match your own vial — it will show the exact insulin-syringe units to draw, the concentration, and how many doses the vial holds.
Add 2 mL of bacteriostatic water to your 5 mg vial. That gives you about 16 doses of 300 mcg. For each dose, draw 12 units into a 100-unit insulin syringe.
See the full Sermorelin dosing chart (units for every dose & water amount), or open the full peptide calculator →
Cautions
- Prescription/compounded where used; otherwise research status.
- Injection-site reactions possible.
- Caution with active malignancy.
Sermorelin FAQ
What is Sermorelin?
A GHRH analog (the first 29 amino acids) that prompts the pituitary to release growth hormone.
How does Sermorelin work?
Binds pituitary GHRH receptors to release endogenous GH. Preserves the body’s natural GH pulse and feedback.
What is Sermorelin used for?
Raising endogenous GH/IGF-1; Age-related GH decline research; Sleep and recovery.
What is a typical Sermorelin dose?
~200–300 mcg, Nightly, Subcutaneous injection. This is a commonly cited figure for context only, not medical advice.
How do you reconstitute Sermorelin?
Often a 5 mg vial. 5 mg with 2 mL water = 2.5 mg/mL, so 300 mcg = 12 units on a U-100 syringe.
What is the half-life of Sermorelin?
Short (~10–20 minutes).