Ipamorelin
A selective growth-hormone-releasing peptide that raises GH with minimal effect on hunger or cortisol.
Ipamorelin at a glance
| Name | Ipamorelin |
|---|---|
| Category | Growth-hormone axis |
| Type | Peptide |
| Sequence | Pentapeptide GH secretagogue |
| Typical dose | ~200–300 mcg per dose |
| Frequency | 1–3× daily, often before bed |
| Route | Subcutaneous injection |
| Half-life | Short (~2 hours). |
Overview
Ipamorelin is a GHRP (growth-hormone-releasing peptide) valued for being “clean” — it prompts a natural GH pulse without the strong hunger, cortisol, or prolactin bumps seen with older GHRPs. It is frequently paired with a GHRH like CJC-1295 (no DAC) because the two work through complementary pathways for a larger, natural pulse.
How it’s thought to work
- Activates the ghrelin/GH-secretagogue receptor to release the body’s own GH.
- Selective — minimal effect on cortisol, prolactin, or appetite.
- Synergizes with GHRH analogs.
Researched uses
- Raising endogenous GH/IGF-1
- Recovery and body-composition research
- Commonly stacked with CJC-1295 (no DAC)
Commonly cited protocol
| Typical dose | ~200–300 mcg per dose |
|---|---|
| Frequency | 1–3× daily, often before bed |
| Route | Subcutaneous injection |
| Notes | Timed away from food/fat for a cleaner GH response. |
Reconstitution
Often a 5 mg vial. 5 mg with 2 mL water = 2.5 mg/mL, so 300 mcg = 12 units on a U-100 syringe.
Ipamorelin dosage calculator
The calculator below is pre-filled with Ipamorelin’s commonly cited vial size and dose. Adjust the vial amount, bacteriostatic water, or dose to match your own vial — it will show the exact insulin-syringe units to draw, the concentration, and how many doses the vial holds.
Add 2 mL of bacteriostatic water to your 5 mg vial. That gives you about 16 doses of 300 mcg. For each dose, draw 12 units into a 100-unit insulin syringe.
See the full Ipamorelin dosing chart (units for every dose & water amount), or open the full peptide calculator →
Cautions
- Not approved for human use.
- Water retention or tingling reported.
- Raises GH/IGF-1 — caution with any active cancer.
Ipamorelin FAQ
What is Ipamorelin?
A selective growth-hormone-releasing peptide that raises GH with minimal effect on hunger or cortisol.
How does Ipamorelin work?
Activates the ghrelin/GH-secretagogue receptor to release the body’s own GH. Selective — minimal effect on cortisol, prolactin, or appetite. Synergizes with GHRH analogs.
What is Ipamorelin used for?
Raising endogenous GH/IGF-1; Recovery and body-composition research; Commonly stacked with CJC-1295 (no DAC).
What is a typical Ipamorelin dose?
~200–300 mcg per dose, 1–3× daily, often before bed, Subcutaneous injection. This is a commonly cited figure for context only, not medical advice.
How do you reconstitute Ipamorelin?
Often a 5 mg vial. 5 mg with 2 mL water = 2.5 mg/mL, so 300 mcg = 12 units on a U-100 syringe.
What is the half-life of Ipamorelin?
Short (~2 hours).