GHRP-1
Also known as: Growth Hormone Releasing Peptide-1
A synthetic growth-hormone-releasing peptide from the same family as GHRP-2 and GHRP-6, studied for its ability to stimulate growth-hormone secretion.
GHRP-1 at a glance
| Name | GHRP-1 |
|---|---|
| Also known as | Growth Hormone Releasing Peptide-1 |
| Category | Growth-hormone axis |
| Type | Peptide |
| Sequence | Ala-His-D-2-methyl-Trp-Ala-Trp-D-Phe-Lys-NH2 |
| Typical dose | ~100 mcg per dose |
| Frequency | One to three times daily in research contexts |
| Route | Subcutaneous injection (research) |
| Half-life | Short - on the order of tens of minutes, consistent with other GHRPs. |
Overview
GHRP-1 is one of the earlier synthetic growth-hormone-releasing peptides developed to probe the growth-hormone secretagogue pathway. Like related GHRPs, it acts on the ghrelin receptor to prompt the pituitary to release growth hormone. It has been used mainly as a research tool, and human clinical data are more limited than for some of its analogues. It is not an approved therapeutic.
How it’s thought to work
- Binds the growth-hormone secretagogue receptor (GHSR), acting as a ghrelin mimetic.
- Appears to stimulate growth-hormone release from the anterior pituitary.
- May also modestly influence prolactin and cortisol in some studies.
- Often described as working synergistically with GHRH analogues on GH output.
Researched uses
- Stimulating endogenous growth-hormone secretion in research
- Investigating the GH secretagogue receptor pathway
- Comparative studies alongside other GHRPs
Commonly cited protocol
| Typical dose | ~100 mcg per dose |
|---|---|
| Frequency | One to three times daily in research contexts |
| Route | Subcutaneous injection (research) |
| Notes | Doses are commonly cited on a per-injection basis, sometimes timed around GHRH co-administration. |
Reconstitution
Commonly supplied as a 5 mg lyophilized vial. Reconstituting 5 mg with 2 mL of bacteriostatic water gives 2.5 mg/mL, so a 100 mcg dose is about 4 units on a U-100 syringe.
GHRP-1 dosage calculator
The calculator below is pre-filled with GHRP-1’s commonly cited vial size and dose. Adjust the vial amount, bacteriostatic water, or dose to match your own vial — it will show the exact insulin-syringe units to draw, the concentration, and how many doses the vial holds.
Add 2 mL of bacteriostatic water to your 5 mg vial. That gives you about 50 doses of 100 mcg. For each dose, draw 4 units into a 100-unit insulin syringe.
See the full GHRP-1 dosing chart (units for every dose & water amount), or open the full peptide calculator →
Cautions
- A research chemical not approved by the FDA for human use; prohibited in competitive sport.
- Human safety and long-term data are limited.
- May transiently raise cortisol and prolactin at higher doses.
- Purity of research-grade material varies by source.
GHRP-1 FAQ
What is GHRP-1?
A synthetic growth-hormone-releasing peptide from the same family as GHRP-2 and GHRP-6, studied for its ability to stimulate growth-hormone secretion.
How does GHRP-1 work?
Binds the growth-hormone secretagogue receptor (GHSR), acting as a ghrelin mimetic. Appears to stimulate growth-hormone release from the anterior pituitary. May also modestly influence prolactin and cortisol in some studies. Often described as working synergistically with GHRH analogues on GH output.
What is GHRP-1 used for?
Stimulating endogenous growth-hormone secretion in research; Investigating the GH secretagogue receptor pathway; Comparative studies alongside other GHRPs.
What is a typical GHRP-1 dose?
~100 mcg per dose, One to three times daily in research contexts, Subcutaneous injection (research). This is a commonly cited figure for context only, not medical advice.
How do you reconstitute GHRP-1?
Commonly supplied as a 5 mg lyophilized vial. Reconstituting 5 mg with 2 mL of bacteriostatic water gives 2.5 mg/mL, so a 100 mcg dose is about 4 units on a U-100 syringe.
What is the half-life of GHRP-1?
Short - on the order of tens of minutes, consistent with other GHRPs.