TB-500
Also known as: Thymosin Beta-4 fragment · TB4
A synthetic version of a thymosin beta-4 region studied for systemic healing, flexibility, and recovery.
TB-500 at a glance
| Name | TB-500 |
|---|---|
| Also known as | Thymosin Beta-4 fragment, TB4 |
| Category | Recovery & tissue repair |
| Type | Peptide |
| Sequence | Synthetic fragment of thymosin beta-4 |
| Typical dose | ~2–2.5 mg |
| Frequency | A couple times weekly (loading), then weekly |
| Route | Subcutaneous injection |
| Half-life | Longer-acting than many peptides; dosed a few times weekly. |
Overview
TB-500 is based on thymosin beta-4, a naturally occurring protein involved in cell migration and tissue repair. In animal research it is associated with faster healing of muscle, tendon, and other tissues, and improved flexibility. It is popular alongside BPC-157 as a “recovery stack,” though human clinical data are limited.
How it’s thought to work
- Regulates actin, helping cells migrate to sites of injury.
- Promotes new blood-vessel growth (angiogenesis) and tissue remodeling.
- Has a systemic, whole-body distribution.
Researched uses
- Soft-tissue and muscle recovery
- Tendon/ligament healing
- Flexibility and injury research
Commonly cited protocol
| Typical dose | ~2–2.5 mg |
|---|---|
| Frequency | A couple times weekly (loading), then weekly |
| Route | Subcutaneous injection |
| Notes | Often cycled and stacked with BPC-157. |
Reconstitution
Often a 10 mg vial. 10 mg with 2 mL water = 5 mg/mL, so a 2 mg dose = 0.4 mL (40 units on a U-100 syringe).
TB-500 dosage calculator
The calculator below is pre-filled with TB-500’s commonly cited vial size and dose. Adjust the vial amount, bacteriostatic water, or dose to match your own vial — it will show the exact insulin-syringe units to draw, the concentration, and how many doses the vial holds.
Add 2 mL of bacteriostatic water to your 10 mg vial. That gives you about 5 doses of 2 mg. For each dose, draw 40 units into a 100-unit insulin syringe.
See the full TB-500 dosing chart (units for every dose & water amount), or open the full peptide calculator →
Cautions
- Not approved for human use; WADA-banned in sport.
- Limited human safety data.
- Theoretical caution with active cancer given pro-angiogenic effects.
TB-500 FAQ
What is TB-500?
A synthetic version of a thymosin beta-4 region studied for systemic healing, flexibility, and recovery.
How does TB-500 work?
Regulates actin, helping cells migrate to sites of injury. Promotes new blood-vessel growth (angiogenesis) and tissue remodeling. Has a systemic, whole-body distribution.
What is TB-500 used for?
Soft-tissue and muscle recovery; Tendon/ligament healing; Flexibility and injury research.
What is a typical TB-500 dose?
~2–2.5 mg, A couple times weekly (loading), then weekly, Subcutaneous injection. This is a commonly cited figure for context only, not medical advice.
How do you reconstitute TB-500?
Often a 10 mg vial. 10 mg with 2 mL water = 5 mg/mL, so a 2 mg dose = 0.4 mL (40 units on a U-100 syringe).
What is the half-life of TB-500?
Longer-acting than many peptides; dosed a few times weekly.