Tesofensine
Also known as: NS2330
An oral, non-peptide triple monoamine reuptake inhibitor commonly cited in the research literature for context on appetite and weight studies.
Tesofensine at a glance
| Name | Tesofensine |
|---|---|
| Also known as | NS2330 |
| Category | Metabolic & weight |
| Type | Amino / injectable |
| Sequence | Non-peptide small molecule. |
| Typical dose | Commonly cited around 0.25-0.5 mg per day in trials |
| Frequency | Once daily |
| Route | Oral |
| Half-life | Long - reported on the order of several days. |
Overview
Tesofensine is an investigational small-molecule compound that inhibits reuptake of noradrenaline, dopamine, and serotonin. It was originally explored for neurodegenerative conditions and later studied for effects on appetite and body weight. It is not an approved therapy in major markets.
How it’s thought to work
- Inhibits reuptake of noradrenaline, dopamine, and serotonin.
- Raises synaptic monoamine levels, associated with reduced appetite.
- Central effects thought to influence energy balance and satiety.
- Acts as an oral small molecule rather than an injectable peptide.
Researched uses
- Weight and body-composition research
- Appetite-regulation studies
- Earlier neurological investigations (historical)
- Metabolic-endpoint clinical trials
Commonly cited protocol
| Typical dose | Commonly cited around 0.25-0.5 mg per day in trials |
|---|---|
| Frequency | Once daily |
| Route | Oral |
| Notes | Taken by mouth; no injection involved. |
Reconstitution
Taken orally as a small molecule, so injection reconstitution and syringe unit math do not apply.
Cautions
- Investigational; not FDA-approved.
- Reported effects on heart rate, blood pressure, and mood in trials.
- Monoamine activity carries interaction and stimulation concerns.
- Provided for education only, not as medical advice.
Tesofensine FAQ
What is Tesofensine?
An oral, non-peptide triple monoamine reuptake inhibitor commonly cited in the research literature for context on appetite and weight studies.
How does Tesofensine work?
Inhibits reuptake of noradrenaline, dopamine, and serotonin. Raises synaptic monoamine levels, associated with reduced appetite. Central effects thought to influence energy balance and satiety. Acts as an oral small molecule rather than an injectable peptide.
What is Tesofensine used for?
Weight and body-composition research; Appetite-regulation studies; Earlier neurological investigations (historical); Metabolic-endpoint clinical trials.
What is a typical Tesofensine dose?
Commonly cited around 0.25-0.5 mg per day in trials, Once daily, Oral. This is a commonly cited figure for context only, not medical advice.
How do you reconstitute Tesofensine?
Taken orally as a small molecule, so injection reconstitution and syringe unit math do not apply.
What is the half-life of Tesofensine?
Long - reported on the order of several days.